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1

Tumor necrosis factor neutralization results in disseminated disease in acute and latent Mycobacterium tuberculosis infection with normal granuloma structure in a cynomolgus macaque model

Philana Ling Lin, Amy Myers, Le'Kneitah Smith, Carolyn Bigbee, Matthew Bigbee, Carl Fuhrman, Heather Grieser, Ion Chiosea, Nikolai N. Voitenek, Saverio V. Capuano, Edwin Klein, JoAnne L. Flynn

Journal:

Arthritis & Rheumatism

Year:

2010

Language:

english

File:

PDF, 213 KB

english, 2010

2

New kids on the block: An old problem for a growing pediatric population

Philana Ling Lin, Michael Green, Marian G. Michaels

Journal:

Pediatric Transplantation

Year:

2005

Language:

english

File:

PDF, 64 KB

english, 2005

3

Immunological concepts in tuberculosis diagnostics for non-human primates: a review

Philana Ling Lin, JoAnn Yee, Edwin Klein, Nicholas W. Lerche

Journal:

Journal of Medical Primatology

Year:

2008

Language:

english

File:

PDF, 210 KB

english, 2008

4

Use of whole genome sequencing to estimate the mutation rate of Mycobacterium tuberculosis during latent infection

Ford, Christopher B, Lin, Philana Ling, Chase, Michael R, Shah, Rupal R, Iartchouk, Oleg, Galagan, James, Mohaideen, Nilofar, Ioerger, Thomas R, Sacchettini, James C, Lipsitch, Marc

Journal:

Nature Genetics

Year:

2011

Language:

english

File:

PDF, 784 KB

english, 2011

5

Tumor Necrosis Factor and Tuberculosis

Lin, Philana Ling, Plessner, Hillarie L, Voitenok, Nikolai N, Flynn, JoAnne L

Journal:

JID Symposium Proceedings

Year:

2007

Language:

english

File:

PDF, 70 KB

english, 2007

6

Nonhuman Primates in Biomedical Research || Tuberculosis Research using Nonhuman Primates

Lin, Philana Ling

Year:

2012

Language:

english

File:

PDF, 1.00 MB

english, 2012

7

The mutation rate of mycobacterial repetitive unit loci in strains ofM. tuberculosisfrom cynomolgus macaque infection

Mark N Ragheb, Christopher B Ford, Michael R Chase, Philana Ling Lin…

Journal:

Year:

2013

Language:

english

File:

PDF, 231 KB

english, 2013

8

Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing

Lin, Philana Ling, Ford, Christopher B, Coleman, M Teresa, Myers, Amy J, Gawande, Richa, Ioerger, Thomas, Sacchettini, James, Fortune, Sarah M, Flynn, JoAnne L

Journal:

Nature Medicine

Year:

2013

Language:

english

File:

PDF, 1.19 MB

english, 2013

9

Pneumonia. Treatment and Diagnosis

Mattila, Joshua T., Fine, Michael J., Limper, Andrew H., Murray, Patrick R., Chen, Bill B., Lin, Philana Ling

Journal:

Annals of the American Thoracic Society

Year:

2014

Language:

english

File:

PDF, 452 KB

english, 2014

10

CD4 T Cell Depletion Exacerbates Acute Mycobacterium tuberculosis While Reactivation of Latent Infection Is Dependent on Severity of Tissue Depletion in Cynomolgus Macaques

Lin, Philana Ling, Rutledge, Tara, Green, Angela M., Bigbee, Matthew, Fuhrman, Carl, Klein, Edwin, Flynn, JoAnne L.

Journal:

AIDS Research and Human Retroviruses

Year:

2012

Language:

english

File:

PDF, 621 KB

english, 2012

11

Comparison of the Effects of Pathogenic Simian Human Immunodeficiency Virus Strains SHIV-89.6P and SHIV-KU2 in Cynomolgus Macaques

Pawar, Santosh N., Mattila, Joshua T., Sturgeon, Timothy J., Lin, Philana Ling, Narayan, Opendra, Montelaro, Ronald C., Flynn, Joanne L.

Journal:

AIDS Research and Human Retroviruses

Year:

2008

Language:

english

File:

PDF, 479 KB

english, 2008

12

A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment

Pienaar, Elsje, Cilfone, Nicholas A., Lin, Philana Ling, Dartois, Véronique, Mattila, Joshua T., Butler, J. Russell, Flynn, JoAnne L., Kirschner, Denise E., Linderman, Jennifer J.

Journal:

Journal of Theoretical Biology

Year:

2015

Language:

english

File:

PDF, 4.73 MB

english, 2015

13

CD8 T cells andMycobacterium tuberculosisinfection

Lin, Philana Ling, Flynn, JoAnne L.

Journal:

Seminars in Immunopathology

Year:

2015

Language:

english

File:

PDF, 1.82 MB

english, 2015

14

Immunology studies in non-human primate models of tuberculosis

Flynn, JoAnne L., Gideon, Hannah P., Mattila, Joshua T., Lin, Philana Ling

Journal:

Immunological Reviews

Year:

2015

Language:

english

File:

PDF, 761 KB

english, 2015

15

Differences in Reactivation of Tuberculosis Induced from Anti-TNF Treatments Are Based on Bioavailability in Granulomatous Tissue

Marino, Simeone, Sud, Dhruv, Plessner, Hillarie, Lin, Philana Ling, Chan, John, Flynn, JoAnne L., Kirschner, Denise E.

Journal:

PLoS Computational Biology

Year:

2007

Language:

english

File:

PDF, 1.16 MB

english, 2007

16

The Effects of B cell Depletion on early Mycobacterium tuberculosis infection in Cynomolgus Macaques

Phuah, Jiayao, Wong, Eileen A., Gideon, Hannah P., Maiello, Pauline, Coleman, M. Teresa, Hendricks, Matthew R., Ruden, Rachel, Cirrincione, Lauren R., Chan, John, Lin, Philana Ling, Flynn, JoAnne L.

Journal:

Infection and Immunity

Year:

2016

Language:

english

File:

PDF, 4.52 MB

english, 2016

17

Early Trends for Invasive Pneumococcal Infections in Children After the Introduction of the 13-valent Pneumococcal Conjugate Vaccine

Kaplan, Sheldon L., Barson, William J., Lin, Philana Ling, Romero, José R., Bradley, John S., Tan, Tina Q., Hoffman, Jill A., Givner, Laurence B., Mason, Edward O.

Journal:

Pediatric Infectious Disease Journal

Year:

2013

Language:

english

File:

PDF, 428 KB

english, 2013

18

CHRONIC GRANULOMATOUS DISEASE IN AN ADOLESCENT WITH RECURRENT IMPETIGO AND CHOLECYSTECTOMY

Scholnicoff, Ellen T., MacGinnitie, Andrew J., Lin, Philana Ling, Darville, Toni

Journal:

Pediatric Infectious Disease Journal

Year:

2009

Language:

english

File:

PDF, 224 KB

english, 2009

19

Diversity of Human and Macaque Airway Immune Cells at Baseline and During Tuberculosis Infection

Silver, Richard F., Myers, Amy J, Jarvela, Jessica, Flynn, JoAnne, Rutledge, Tara, Bonfield, Tracey, Lin, Philana Ling

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

2016

Language:

english

File:

PDF, 17.90 MB

english, 2016

20

Early Whole Blood Transcriptional Signatures Are Associated with Severity of Lung Inflammation in Cynomolgus Macaques with Mycobacterium tuberculosis Infection

Gideon, Hannah P., Skinner, Jason A., Baldwin, Nicole, Flynn, JoAnne L., Lin, Philana Ling

Journal:

The Journal of Immunology

Year:

2016

Language:

english

File:

PDF, 3.04 MB

english, 2016

21

Emergence of Multidrug-resistant Pneumococcal Serotype 35B among U.S. Children

Olarte, Liset, Kaplan, Sheldon L., Barson, William J., Romero, José R., Lin, Philana Ling, Tan, Tina Q., Hoffman, Jill A., Bradley, John S., Givner, Laurence B., Mason, Edward O., Hultén, Kristina G.

Journal:

Journal of Clinical Microbiology

Year:

2016

Language:

english

File:

PDF, 1.34 MB

english, 2016

22

Invasive pneumococcal infections in children following transplantation in the pneumococcal conjugate vaccine era

Olarte, Liset, Lin, Philana Ling, Barson, William J., Romero, Jose R., Tan, Tina Q., Givner, Laurence B., Hoffman, Jill A., Bradley, John S., Hultén, Kristina G., Mason, Edward O., Kaplan, Sheldon L.

Journal:

Transplant Infectious Disease

Year:

2017

Language:

english

File:

PDF, 457 KB

english, 2017

23

Pneumococcal Invasive Disease in Infants Younger Than 60 Days in the United States in the 13-Valent Pneumococcal Conjugate Vaccine Era

Olarte, Liset, Barson, William J., Bradley, John S., Tan, Tina, Lin, Philana Ling, Romero, Jose R., Givner, Laurence B., Hoffman, Jill, Hulten, Kristina, Mason, Edward, Kaplan, Sheldon L.

Journal:

Open Forum Infectious Diseases

Year:

2016

Language:

english

File:

PDF, 101 KB

english, 2016

24

Globalization of pediatric transplantation: The risk of tuberculosis or not tuberculosis

McCulloch, Mignon, Lin, Philana Ling

Journal:

Pediatric Transplantation

Year:

2017

Language:

english

File:

PDF, 231 KB

english, 2017

25

Pneumococcal Pneumonia Requiring Hospitalization in U.S. Children in the 13-Valent Pneumococcal Conjugate Vaccine Era

Olarte, Liset, Barson, William J., Barson, Ryan M., Romero, José R., Bradley, John S., Tan, Tina Q., Givner, Laurence B., Hoffman, Jill A., Lin, Philana Ling, Hultén, Kristina G., Mason, Edward O., Ka

Journal:

Clinical Infectious Diseases

Year:

2017

Language:

english

File:

PDF, 700 KB

english, 2017

26

Digitally Barcoding Mycobacterium tuberculosis Reveals In Vivo Infection Dynamics in the Macaque Model of Tuberculosis

Martin, Constance J., Cadena, Anthony M., Leung, Vivian W., Lin, Philana Ling, Maiello, Pauline, Hicks, Nathan, Chase, Michael R., Flynn, JoAnne L., Fortune, Sarah M., Stallings, Christina L.

Journal:

Year:

2017

Language:

english

File:

PDF, 1.24 MB

english, 2017

27

Invasive Pneumococcal Disease in Infants Aged 0–60 Days in the United States in the 13-Valent Pneumococcal Conjugate Vaccine Era

Olarte, Liset, Barson, William J., Bradley, John S., Tan, Tina Q., Lin, Philana Ling, Romero, José R., Givner, Laurence B., Hoffman, Jill A., Hultén, Kristina G., Mason, Edward O., Kaplan, Sheldon L.

Journal:

Journal of the Pediatric Infectious Diseases Society

Year:

2017

Language:

english

File:

PDF, 162 KB

english, 2017

28

Osteoarticular Infections Caused by Streptococcus pneumoniae in Children in the Post Pneumococcal Conjugate Vaccine Era

Olarte, Liset, Romero, Jose, Barson, William, Bradley, John, Lin, Philana Ling, Givner, Laurence, Tan, Tina, Hoffman, Jill, Hultén, Kristina G., Mason, Edward O., Kaplan, Sheldon L.

Journal:

Pediatric Infectious Disease Journal

Year:

2017

Language:

english

File:

PDF, 1.31 MB

english, 2017

29

Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

White, Alexander G., Maiello, Pauline, Coleman, M. Teresa, Tomko, Jaime A., Frye, L. James, Scanga, Charles A., Lin, Philana Ling, Flynn, JoAnne L.

Journal:

Journal of Visualized Experiments

Year:

2017

Language:

english

File:

PDF, 956 KB

english, 2017

30

Rhesus macaques are more susceptible to progressive tuberculosis than cynomolgus macaques: A quantitative comparison

Maiello, Pauline, DiFazio, Robert M., Cadena, Anthony M., Rodgers, Mark A., Lin, Philana Ling, Scanga, Charles A., Flynn, JoAnne L.

Journal:

Infection and Immunity

Year:

2017

Language:

english

File:

PDF, 2.67 MB

english, 2017

31

Blood RNA signatures prospectively discriminate controllers from progressors early after low-dose M. tuberculosis infection of cynomolgus macaques

Thompson, Ethan G, Shankar, Smitha, Gideon, Hannah P, Braun, Jackie, Valvo, Joe, Skinner, Jason, Aderem, Alan, Flynn, JoAnne L, Lin, Philana Ling, Zak, Daniel E

Journal:

The Journal of Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 677 KB

english, 2018

32

Invasive Pneumococcal Infections in Children Following Transplantation in the Pneumococcal Conjugate Vaccine Era

Olarte, Liset, Lin, Philana Ling, Barson, William J., Romero, Jose R., Hoffman, Jill, Givner, Laurence B., Bradley, John S., Tan, Tina, Hulten, Kristina G., Mason, Edward O., Kaplan, Sheldon L.

Journal:

Open Forum Infectious Diseases

Year:

2015

Language:

english

File:

PDF, 51 KB

english, 2015

33

Low levels of T cell exhaustion in tuberculous lung granulomas

Wong, Eileen A., Joslyn, Louis, Grant, Nicole L., Klein, Edwin, Lin, Philana Ling, Kirschner, Denise E., Flynn, JoAnne L.

Journal:

Infection and Immunity

Year:

2018

Language:

english

File:

PDF, 7.13 MB

english, 2018

34

Identification of Mycobacterium tuberculosis using volatile biomarkers in culture and exhaled breath

Mellors, Theodore Robert, Nasir, Mavra, Franchina, Flavio Antonio, Smolinska, Agnieszka, Blanchet, Lionel, Flynn, JoAnne, Tomko, Jaime A, O'Malley, Melanie Joy, Scanga, Charles A, Lin, Philana Ling, W

Journal:

Journal of Breath Research

Year:

2018

Language:

english

File:

PDF, 1.56 MB

english, 2018

35

Invasive Serotype 35B Pneumococci Including an Expanding Serotype Switch Lineage

Olarte, Liset, Kaplan, Sheldon L., Barson, William J., Romero, José R., Lin, Philana Ling, Tan, Tina Q., Hoffman, Jill A., Bradley, John S., Givner, Laurence B., Mason, Edward O., Hultén, Kristina G.

Journal:

Emerging Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 314 KB

english, 2018

36

Spatial and temporal evolution of lung granulomas in a cynomolgus macaque model of Mycobacterium tuberculosis infection

Gregg, Robert W., Maiello, Pauline, Borish, H. Jacob, Coleman, M. Teresa, Reed, Douglas S., White, Alexander G., Flynn, JoAnne L., Lin, Philana Ling

Journal:

Radiology of Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 1.22 MB

english, 2018

37

Profiling the airway in the macaque model of tuberculosis reveals variable microbial dysbiosis and alteration of community structure

Cadena, Anthony M, Ma, Yixuan, Ding, Tao, Bryant, MacKenzie, Maiello, Pauline, Geber, Adam, Lin, Philana Ling, Flynn, JoAnne L, Ghedin, Elodie

Journal:

Year:

2018

Language:

english

File:

PDF, 1.24 MB

english, 2018

38

Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques

Cadena, Anthony M., Hopkins, Forrest F., Maiello, Pauline, Carey, Allison F., Wong, Eileen A., Martin, Constance J., Gideon, Hannah P., DiFazio, Robert M., Andersen, Peter, Lin, Philana Ling, Fortune,

Journal:

Year:

2018

Language:

english

File:

PDF, 4.19 MB

english, 2018

39

The End of the Binary Era: Revisiting the Spectrum of Tuberculosis

Lin, Philana Ling, Flynn, JoAnne L.

Journal:

The Journal of Immunology

Year:

2018

Language:

english

File:

PDF, 1.38 MB

english, 2018

40

Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques

Ganchua, Sharie Keanne C., Cadena, Anthony M., Maiello, Pauline, Gideon, Hannah P., Myers, Amy J., Junecko, Beth F., Klein, Edwin C., Lin, Philana Ling, Mattila, Joshua T., Flynn, JoAnne L., Behr, Mar

Journal:

Year:

2018

Language:

english

File:

PDF, 3.93 MB

english, 2018

41

CD 4 CD 8 Double Positive T cell responses during Mycobacterium tuberculosis infection in cynomolgus macaques

Diedrich, Collin Richard, Gideon, Hannah Priyadarshini, Rutledge, Tara, Baranowski, Tonilynn Marie, Maiello, Pauline, Myers, Amy J., Lin, Philana Ling

Journal:

Journal of Medical Primatology

Year:

2019

Language:

english

File:

PDF, 546 KB

english, 2019

42

Analysis of Invasive Pneumococcal Infections Due to 13-Pneumococcal Conjugate Vaccine Serotypes at 8 US Children’s Hospitals During 2014 to 2016

Kaplan, Sheldon L, Barson, William J, Lin, Philana Ling, Romero, Jose R, Bradley, John S, Tan, Tina, Givner, Laurence B, Hoffman, Jill, Hulten, Kristina, Mason, Edward O

Journal:

Open Forum Infectious Diseases

Year:

2017

File:

PDF, 329 KB

2017

43

Invasive Pneumococcal Disease in Children’s Hospitals: 2014–2017

Kaplan, Sheldon L., Barson, William J., Lin, Philana Ling, Romero, José R., Bradley, John S., Tan, Tina Q., Pannaraj, Pia S., Givner, Laurence B., Hulten, Kristina G.

Journal:

Year:

2019

Language:

english

File:

PDF, 899 KB

english, 2019

44

Invasive Pneumococcal Disease in Children’s Hospitals: 2014–2017

Kaplan, Sheldon L., Barson, William J., Lin, Philana Ling, Romero, José R., Bradley, John S., Tan, Tina Q., Pannaraj, Pia S., Givner, Laurence B., Hulten, Kristina G.

Journal:

Year:

2019

File:

PDF, 899 KB

2019

45

77Continued Decline in Invasive Pneumococcal Infections in Children Among 8 Children's Hospitals in the United States 2011 to 2013

Kaplan, Sheldon L., Barson, William J., Lin, Philana Ling, Romero, Jose, Bradley, John S., Tan, Tina, Hoffman, Jill, Givner, Laurence B., Hulten, Kristina G., Mason, Edward

Journal:

Open Forum Infectious Diseases

Year:

2014

Language:

english

File:

PDF, 78 KB

english, 2014